Activation of Histidine Kinase SpaK Is Mediated by the N-Terminal Portion of Subtilin-Like Lantibiotics and Is Independent of Lipid II

The biosynthesis of the lantibiotic subtilin is autoinduced in a quorum-sensing mechanism via histidine kinase SpaK. Subtilin-like lantibiotics, such as entianin, ericin S, and subtilin, specifically activated SpaK in a comparable manner, whereas the structurally similar nisin did not provide the si...

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Bibliographic Details
Published in:Appl Environ Microbiol
Main Authors: Spieß, Tobias, Korn, Sophie Marianne, Kötter, Peter, Entian, Karl-Dieter
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Biotechnology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510167/
https://ncbi.nlm.nih.gov/pubmed/26025904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01368-15
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