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Resistance to Trastuzumab in Breast Cancer

HER2 is a transmembrane oncoprotein encoded by the HER2/neu gene and is overexpressed in approximately 20 to 25% of invasive breast cancers. It can be therapeutically targeted by trastuzumab, a humanized IgG1 kappa light chain monoclonal antibody. Although trastuzumab is currently considered one of...

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Bibliographic Details
Main Authors: Pohlmann, Paula R., Mayer, Ingrid A., Mernaugh, Ray
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471537/
https://ncbi.nlm.nih.gov/pubmed/20008848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0636
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