Sedlin Controls the ER Export of Procollagen by Regulating the Sar1 Cycle

Newly synthesized proteins exit the endoplasmic reticulum (ER) via coat protein complex II (COPII) vesicles. Procollagen (PC), however, forms prefibrils that are too large to fit into typical COPII vesicles; PC thus needs large transport carriers, which we term megacarriers. TANGO1 assists PC packin...

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Auteurs principaux: Venditti, Rossella, Scanu, Tiziana, Santoro, Michele, Di Tullio, Giuseppe, Spaar, Alexander, Gaibisso, Renato, Beznoussenko, Galina V., Mironov, Alexander A., Mironov, Alexander, Zelante, Leopoldo, Piemontese, Maria Rosaria, Notarangelo, Angelo, Malhotra, Vivek, Vertel, Barbara M., Wilson, Cathal, De Matteis, Maria Antonietta
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471527/
https://ncbi.nlm.nih.gov/pubmed/23019651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1224947
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