Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells

Interferon (IFN-α) is effective therapy for polycythemia vera (PV) patients, but it is frequently interrupted because of adverse events. To permit the long-term use of IFN, we propose combining low doses of IFN with Nutlin-3, an antagonist of MDM2, which is also capable of promoting PV CD34(+) cell...

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Detalhes bibliográficos
Main Authors: Lu, Min, Wang, Xiaoli, Li, Yan, Tripodi, Joseph, Mosoyan, Goar, Mascarenhas, John, Kremyanskaya, Marina, Najfeld, Vesna, Hoffman, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471518/
https://ncbi.nlm.nih.gov/pubmed/22872685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-410712
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