Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role

Tumor cells can induce certain cytokines and soluble receptors that have a suppressive effect on the immune system. In this study, we showed that an extracellular portion of a membrane-bound ligand of CD40 (soluble CD40 ligand; sCD40L) was significantly elevated in the serum of cancer patients compa...

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Bibliographic Details
Main Authors: Huang, Jianping, Jochems, Caroline, Talaie, Tara, Anderson, Austin, Jales, Alessandra, Tsang, Kwong Y., Madan, Ravi A., Gulley, James L., Schlom, Jeffrey
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471513/
https://ncbi.nlm.nih.gov/pubmed/22932804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-427799
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