Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1

Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disorder caused by the expansion of CAG repeats in the ataxin 1 (ATXN1) gene. In affected cerebellar neurons of patients, mutant ATXN1 accumulates in ubiquitin-positive nuclear inclusions, indicating that protein misfolding is involved in S...

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Bibliografski detalji
Glavni autori: Persengiev, Stephan, Kondova, Ivanela, Bontrop, Ronald E.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471453/
https://ncbi.nlm.nih.gov/pubmed/23094141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/672536
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