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Interaction of the S6 Proline Hinge with N-Type and C-Type Inactivation in Kv1.4 Channels
Several voltage-gated channels share a proline-valine-proline (proline hinge) sequence motif at the intracellular side of S6. We studied the proline hinge in Kv1.4 channels, which inactivate via two mechanisms: N- and C-type. We mutated the second proline to glycine or alanine: P558A, P558G. These m...
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| Päätekijät: | , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Biophysical Society
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471450/ https://ncbi.nlm.nih.gov/pubmed/23062336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.08.036 |
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