Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB

BACKGROUND: TIR-domain-containing adapter-inducing interferon-β (TRIF) is the sole downstream adaptor of Toll-like receptor (TLR)3, which is one of the major signaling pathways in immune cells leading to neuroinflammation in the central nervous system. Overexpression of TRIF may lead to activation o...

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Autori principali: Lin, Sen, Liang, Yajie, Zhang, Jiqiang, Bian, Chen, Zhou, Hongli, Guo, Qiang, Xiong, Ying, Li, Shurong, Su, Bingyin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471332/
https://ncbi.nlm.nih.gov/pubmed/22361049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-39
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