Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration

Migrating cells acquire front-rear polarity with a leading edge and a trailing tail for directional movement. The Rac exchange factor Tiam1 participates in polarized cell migration with the PAR complex of PAR3, PAR6, and atypical protein kinase C. However, it remains largely unknown how Tiam1 is reg...

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Bibliografiske detaljer
Main Authors: Wang, Shujie, Watanabe, Takashi, Matsuzawa, Kenji, Katsumi, Akira, Kakeno, Mai, Matsui, Toshinori, Ye, Feng, Sato, Kazuhide, Murase, Kiyoko, Sugiyama, Ikuko, Kimura, Kazushi, Mizoguchi, Akira, Ginsberg, Mark H., Collard, John G., Kaibuchi, Kozo
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2012
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471226/
https://ncbi.nlm.nih.gov/pubmed/23071154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201202041
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