alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.

The role of ornithine decarboxylase (OrnDCase, EC 4.1.1.17) and of the polyamines [putrescine (Put), spermidine (Spd), and spermine (Spm)] in mouse skin tumor promotion was investigated by the use of alpha-difluoromethylornithine (CHF2-Orn), an enzyme-activated irreversible inhibitor of OrnDCase. 12...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Weeks, C E, Herrmann, A L, Nelson, F R, Slaga, T J
Format: Artigo
Langue:Inglês
Publié: 1982
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC347045/
https://ncbi.nlm.nih.gov/pubmed/6821130
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires