Ornithine decarboxylase in Pneumocystis carinii and implications for therapy.

Pneumocystis carinii pneumonia (PCP) can be treated with eflornithine (difluoromethylornithine, DFMO, Ornidyl), a competitive irreversible inhibitor of ornithine decarboxylase (ODC), a key enzyme for polyamine biosynthesis. Because ODC has been reported to be absent from P. carinii, it has been assu...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Sarić, M, Clarkson, A B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188239/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7872745/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.11.2545
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