Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Insulin resistance in skeletal muscle and liver may play a primary role in the development of type 2 diabetes mellitus, and the mechanism by which insulin resistance occurs may be related to alterations in fat metabolism. Transgenic mice with muscle- and liver-specific overexpression of lipoprotein...

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Main Authors: Kim, Jason K., Fillmore, Jonathan J., Chen, Yan, Yu, Chunli, Moore, Irene K., Pypaert, Marc, Lutz, E. Peer, Kako, Yuko, Velez-Carrasco, Wanda, Goldberg, Ira J., Breslow, Jan L., Shulman, Gerald I.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC34701/
https://ncbi.nlm.nih.gov/pubmed/11390966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121164498
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