Neoantigen and tumor antigen-specific immunity transferred from immunized donors is detectable early after allogeneic transplantation in myeloma patients

To enhance the therapeutic index of allogeneic hematopoietic stem cell transplantation (HSCT), we immunized ten HLA-matched sibling donors prior to stem cell collection with recipient-derived clonal myeloma immunoglobulin, idiotype (Id), as a tumor antigen, conjugated with keyhole limpet hemocyanin...

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Autors principals: Foglietta, Myriam, Neelapu, Sattva S., Kwak, Larry W., Jiang, Yunfang, Nattamai, Durga, Lee, Seung-Tae, Fowler, Daniel H., Sportes, Claude, Gress, Ronald E., Steinberg, Seth M., Vence, Luis M., Radvanyi, Laszlo, Dwyer, Karen C., Qazilbash, Muzzaffar H., Bryant, Kelly, Bishop, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469751/
https://ncbi.nlm.nih.gov/pubmed/22773122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bmt.2012.132
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