Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium

Reduced myofibrillar ATP availability during prolonged myocardial ischemia may limit post-ischemic mechanical function. Because creatine kinase (CK) is the prime energy reserve reaction of the heart and because it has been difficult to augment ATP synthesis during and after ischemia, we used mice th...

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Détails bibliographiques
Auteurs principaux: Akki, Ashwin, Su, Jason, Yano, Toshiyuki, Gupta, Ashish, Wang, Yibin, Leppo, Michelle K., Chacko, Vadappuram P., Steenbergen, Charles, Weiss, Robert G.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2012
Sujets:
Energetics and Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469706/
https://ncbi.nlm.nih.gov/pubmed/22886411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00268.2012
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