Activated hepatic stellate cells upregulate transcription of ecto-5′-nucleotidase/CD73 via specific SP1 and SMAD promoter elements

Adenosine is a potent modulator of liver fibrosis and inflammation. Adenosine has been shown to regulate such diverse activities as chemotaxis, contraction, and matrix production in hepatic stellate cells (HSC). Ecto-5′-nucleotidase/CD73 [EC 3.1.3.5] is the rate-limiting enzyme in adenosine producti...

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Hlavní autoři: Fausther, Michel, Sheung, Nina, Saiman, Yedidya, Bansal, Meena B., Dranoff, Jonathan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Liver and Biliary Tract
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469697/
https://ncbi.nlm.nih.gov/pubmed/22899823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00015.2012
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