Immunogenicity and Efficacy of Intramuscular Replication-Defective and Subunit Vaccines against Herpes Simplex Virus Type 2 in the Mouse Genital Model

Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus that is highly prevalent worldwide, causing a range of symptoms that result in significant healthcare costs and human suffering. ACAM529 is a replication-defective vaccine candidate prepared by growing the previously described dl5-2...

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Main Authors: Delagrave, Simon, Hernandez, Hector, Zhou, Changhong, Hamberger, John F., Mundle, Sophia T., Catalan, John, Baloglu, Simge, Anderson, Stephen F., DiNapoli, Joshua M., Londoño-Hayes, Patricia, Parrington, Mark, Almond, Jeffrey, Kleanthous, Harry
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469653/
https://ncbi.nlm.nih.gov/pubmed/23071620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046714
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