Cyclin D(2) rescues size and function of GATA4 haplo-insufficient hearts

Transcription factor GATA4 is a key regulator of cardiomyocyte growth, and differentiation and 50% reduction in GATA4 levels results in hypoplastic hearts. Search for GATA4 targets/effectors revealed cyclin D(2) (CD2), a member of the D-type cyclins (D(1), D(2), and D(3)) that play a vital role in c...

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Библиографические подробности
Главные авторы: Yamak, Abir, Temsah, Rana, Maharsy, Wael, Caron, Sophie, Paradis, Pierre, Aries, Anne, Nemer, Mona
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2012
Предметы:
Integrative Cardiovascular Physiology and Pathophysiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469642/
https://ncbi.nlm.nih.gov/pubmed/22923619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00250.2012
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