Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

BACKGROUND: Celiac disease (CD) is caused by an uncontrolled immune response to gluten, a heterogeneous mixture of wheat storage proteins. The CD-toxicity of these proteins and their derived peptides is depending on the presence of specific T-cell epitopes (9-mer peptides; CD epitopes) that mediate...

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Main Authors: Salentijn, Elma MJ, Mitea, D Cristina, Goryunova, Svetlana V, van der Meer, Ingrid M, Padioleau, Ismael, Gilissen, Luud JWJ, Koning, Frits, Smulders, Marinus JM
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469346/
https://ncbi.nlm.nih.gov/pubmed/22726570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-277
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