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Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (−)-Cocaine

Reaction pathway of (−)-cocaine hydrolysis catalyzed by our recently discovered most efficient cocaine hydrolase, which is the A199S/F227A/S287G/A328W/Y332G mutant of human butyrylcholinesterase (BChE), and the corresponding free energy profile have been studied by performing first-principles pseudo...

詳細記述

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書誌詳細
主要な著者: Liu, Junjun, Zhan, Chang-Guo
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469271/
https://ncbi.nlm.nih.gov/pubmed/23066354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct200810d
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