C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

Induction of the C/EBP homologous protein (CHOP) is considered a key event for endoplasmic reticulum (ER) stress-mediated apoptosis. Type 1 diabetes (T1D) is characterized by an autoimmune destruction of the pancreatic β-cells. Pro-inflammatory cytokines are early mediators of β-cell death in T1D. C...

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Detalhes bibliográficos
Main Authors: Allagnat, F, Fukaya, M, Nogueira, T C, Delaroche, D, Welsh, N, Marselli, L, Marchetti, P, Haefliger, J A, Eizirik, D L, Cardozo, A K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469067/
https://ncbi.nlm.nih.gov/pubmed/22653339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.67
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