CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma

The unfolded protein response (UPR) is generally activated in solid tumors and results in tumor cell anti-apoptosis and drug resistance. However, tumor-specific UPR transducers are largely unknown. In the present study, we identified CD147, a cancer biomarker, as an UPR inducer in hepatocellular car...

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Autors principals: Tang, J, Guo, Y-S, Zhang, Y, Yu, X-L, Li, L, Huang, W, Li, Y, Chen, B, Jiang, J-L, Chen, Z-N
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469060/
https://ncbi.nlm.nih.gov/pubmed/22595757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.60
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