Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons

Peripheral nerve injury triggers the activation of RhoA in spinal motor and peripheral sensory neurons. RhoA activates a number of effector proteins including the Rho-associated kinase, ROCK, which targets the cytoskeleton and leads to inhibition of neurite outgrowth. Blockade of the Rho/ROCK pathwa...

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Autori principali: Auer, Maria, Schweigreiter, Rüdiger, Hausott, Barbara, Thongrong, Sitthisak, Höltje, Markus, Just, Ingo, Bandtlow, Christine, Klimaschewski, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2012
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468917/
https://ncbi.nlm.nih.gov/pubmed/23087613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2012.00043
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