Tumor Necrosis Factor Inhibits Neurite Outgrowth and Branching of Hippocampal Neurons by a Rho-Dependent Mechanism

In response to injury and inflammation of the CNS, brain cells including microglia and astrocytes secrete tumor necrosis factor-α (TNF). This pro-inflammatory cytokine has been implicated in both neuronal cell death and survival. We now provide evidence that TNF affects the formation of neurites. Ne...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Neumann, Harald, Schweigreiter, Rüdiger, Yamashita, Toshihide, Rosenkranz, Katja, Wekerle, Hartmut, Barde, Yves-Alain
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758473/
https://ncbi.nlm.nih.gov/pubmed/11826115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-03-00854.2002
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