Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules

The H-2L(d) alloreactive 2C T cell receptor (TCR) is commonly considered as being positively selected on the H-2K(b) molecule. Surprisingly, 2C TCR(+) CD8(+) single-positive T cells emerge in massive numbers in fetal thymic organ culture originating from 2C transgenic, H-2K(b)D(b−/−) (2C(+)K(b)D(b−/...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Maurice, Madelon M., Gould, Dina S., Carroll, John, Vugmeyster, Yulia, Ploegh, Hidde L.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2001
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34687/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11404484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141143298
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