Combinatorial Pharmacogenetic Interactions of Bucindolol and β(1), α(2C) Adrenergic Receptor Polymorphisms

BACKGROUND: Pharmacogenetics involves complex interactions of gene products affecting pharmacodynamics and pharmacokinetics, but there is little information on the interaction of multiple genetic modifiers of drug response. Bucindolol is a β-blocker/sympatholytic agent whose efficacy is modulated by...

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Main Authors: O'Connor, Christopher M., Fiuzat, Mona, Carson, Peter E., Anand, Inder S., Plehn, Jonathan F., Gottlieb, Stephen S., Silver, Marc A., Lindenfeld, JoAnn, Miller, Alan B., White, Michel, Walsh, Ryan, Nelson, Penny, Medway, Allen, Davis, Gordon, Robertson, Alastair D., Port, J. David, Carr, James, Murphy, Guinevere A., Lazzeroni, Laura C., Abraham, William T., Liggett, Stephen B., Bristow, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468617/
https://ncbi.nlm.nih.gov/pubmed/23071495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044324
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