Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells

BACKGROUND & AIMS: Hepatitis C virus (HCV) is difficult to eradicate and type III interferons (IFN-λ, composed of IL-28A, IL-28B and IL-29) are novel therapeutic candidates. We hypothesized that IFN-λ have immunomodulatory effects in HCV- infected individuals. MATERIALS AND METHODS: We analyzed...

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Hauptverfasser: Dolganiuc, Angela, Kodys, Karen, Marshall, Christopher, Saha, Banishree, Zhang, Shuye, Bala, Shashi, Szabo, Gyongyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468613/
https://ncbi.nlm.nih.gov/pubmed/23071503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044915
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