The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils

The G(i)-coupled P2Y(14) receptor (P2Y(14)-R) is potently activated by UDP-sugars and UDP. Although P2Y(14)-R mRNA is prominently expressed in circulating neutrophils, the signaling pathways and functional responses associated with this receptor are undefined. In this study, we illustrate that incub...

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Hlavní autoři: Sesma, Juliana I., Kreda, Silvia M., Steinckwich-Besancon, Natacha, Dang, Hong, García-Mata, Rafael, Harden, T. Kendall, Lazarowski, Eduardo R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468347/
https://ncbi.nlm.nih.gov/pubmed/22673622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00138.2012
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