Inhibition of Mammalian Target of Rapamycin in Human Acute Myeloid Leukemia Cells Has Diverse Effects That Depend on the Environmental In Vitro Stress

Effects of the mTOR inhibitor rapamycin were characterized on in vitro cultured primary human acute myeloid leukemia (AML) cells and five AML cell lines. Constitutive mTOR activation seemed to be a general characteristic of primary AML cells. Increased cellular stress induced by serum deprivation in...

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Autores principales: Ryningen, Anita, Reikvam, Håkon, Nepstad, Ina, Paulsen Rye, Kristin, Bruserud, Øystein
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467767/
https://ncbi.nlm.nih.gov/pubmed/23082251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/329061
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