Opiate antagonistic properties of an octapeptide somatostatin analog.

The somatostatin analog D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-NH-CH(CH2OH)CHOHCH3 (SMS 201-995) displaces [3h[naloxone from its binding sites (IC50, 38 +/- 60 nM), being more than 200 times more potent than somatostatin. As measured by the difference between [3H]dihydromorphine, [3H][D-Ala2,D-Leu5]enkepha...

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Detalles Bibliográficos
Main Authors: Maurer, R, Gaehwiler, B H, Buescher, H H, Hill, R C, Roemer, D
Formato: Artigo
Idioma:Inglês
Publicado: 1982
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC346769/
https://ncbi.nlm.nih.gov/pubmed/6126877
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