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Direct Assessment of the Effect of the Gly380Arg Achondroplasia Mutation on FGFR3 Dimerization Using Quantitative Imaging FRET

The Gly380Arg mutation in FGFR3 is the genetic cause for achondroplasia (ACH), the most common form of human dwarfism. The mutation has been proposed to increase FGFR3 dimerization, but the dimerization propensities of wild-type and mutant FGFR3 have not been compared. Here we use quantitative imagi...

詳細記述

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書誌詳細
主要な著者: Placone, Jesse, Hristova, Kalina
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467271/
https://ncbi.nlm.nih.gov/pubmed/23056398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046678
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