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The Prognostic Value of BRAF Mutation in Colorectal Cancer and Melanoma: A Systematic Review and Meta-Analysis

BACKGROUND: Mutation of BRAF is a predominant event in cancers with poor prognosis such as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of mitogen activated protein kinase pathway which is essential for cell proliferation and tumor progression. Despite tremendous...

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Detalhes bibliográficos
Main Authors: Safaee Ardekani, Gholamreza, Jafarnejad, Seyed Mehdi, Tan, Larry, Saeedi, Ardavan, Li, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467229/
https://ncbi.nlm.nih.gov/pubmed/23056577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047054
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