Phosphorothioate DNA as an antioxidant in bacteria

Diverse bacteria contain DNA with sulfur incorporated stereo-specifically into their DNA backbone at specific sequences (phosphorothioation). We found that in vitro oxidation of phosphorothioate (PT) DNA by hydrogen peroxide (H(2)O(2)) or peracetic acid has two possible outcomes: DNA backbone cleava...

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Autori principali: Xie, Xinqiang, Liang, Jingdan, Pu, Tianning, Xu, Fei, Yao, Fen, Yang, Yan, Zhao, Yi-Lei, You, Delin, Zhou, Xiufen, Deng, Zixin, Wang, Zhijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467049/
https://ncbi.nlm.nih.gov/pubmed/22772986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks650
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