Integrated Computational and Experimental Analysis of the Neuroendocrine Transcriptome in Genetic Hypertension Identifies Novel Control Points for the Cardio-Metabolic Syndrome

BACKGROUND: METHODS AND RESULTS: We developed a novel, integrative method (combining animal models, transcriptomics, bioinformatics, molecular biology, and trait-extreme phenotypes) to identify candidate genes for essential hypertension and the metabolic syndrome. We first undertook transcriptome pr...

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Auteurs principaux: Friese, Ryan S., Ye, Chun, Nievergelt, Caroline M., Schork, Andrew J., Mahapatra, Nitish R., Rao, Fangwen, Napolitan, Philip S., Waalen, Jill, Ehret, Georg B., Munroe, Patricia B., Schmid-Schönbein, Geert W., Eskin, Eleazar, O’Connor, Daniel T.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467001/
https://ncbi.nlm.nih.gov/pubmed/22670052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.111.962415
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