A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment

Platelets play a supportive role in tumor metastasis. Impairment of platelet function within the tumor microenvironment may provide a clinically useful approach to inhibit metastasis. We developed a novel humanized single-chain antibody (scFv Ab) against integrin GPIIIa49-66 (named A11) capable of l...

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Bibliographic Details
Main Authors: Zhang, Wei, Dang, Suying, Hong, Tao, Tang, Jian, Fan, Jing, Bu, Dawei, Sun, Yanjie, Wang, Zhugang, Wisniewski, Thomas
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466970/
https://ncbi.nlm.nih.gov/pubmed/22879538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-425207
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