Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice

Inhibition of leukocyte adhesion to the vascular endothelium represents a novel and important approach for decreasing sickle cell disease (SCD) vaso-occlusion. Using a humanized SCD–mouse-model of tumor necrosis factor-α–induced acute vaso-occlusion, we herein present data demonstrating that short-t...

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Hlavní autoři: Almeida, Camila Bononi, Scheiermann, Christoph, Jang, Jung-Eun, Prophete, Colette, Costa, Fernando Ferreira, Conran, Nicola, Frenette, Paul S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466969/
https://ncbi.nlm.nih.gov/pubmed/22833547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-409524
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