Disruption of Npr1 gene differentially regulates the juxtaglomerular and distal tubular renin levels in null mutant mice

Atrial natriuretic peptide (ANP) exerts an inhibitory effect on juxtaglomerular (JG) renin synthesis and release by activating guanylyl cyclase/ natriuretic peptide receptor-A (GC-A/NPRA). Renin has also been localized in connecting tubule cells; however, the effect of ANP/NPRA signaling on tubular...

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Main Authors: Prieto, Minolfa C, Das, Subhankar, Somanna, Naveen K, Harrison-Bernard, Lisa M, Navar, L Gabriel, Pandey, Kailash N
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2012
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466495/
https://ncbi.nlm.nih.gov/pubmed/23071870
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