N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells

Methamphetamine- (MA-) induced neurotoxicity is associated with mitochondrial dysfunction and enhanced oxidative stress. Our previous study demonstrated that MA induces autophagy in a dopaminergic neuronal cell model (N27 cells). The cellular mechanisms underlying MA-induced autophagy and apoptosis...

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Bibliographic Details
Main Authors: Chandramani Shivalingappa, Prashanth, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha, Kanthasamy, Arthi
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465903/
https://ncbi.nlm.nih.gov/pubmed/23056996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/424285
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