An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

We have developed a methotrexate-resistant Chinese hamster ovary cell line (CHOC 400) containing a 500-fold amplification of a 135-kilobase chromosomal DNA sequence. This sequence includes the gene for dihydrofolate reductase (tetrahydrofolate dehydrogenase, 5,6,7,8-tetrahydrofolate: NADP+ oxidoredu...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Heintz, N H, Hamlin, J L
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1982
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346581/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6955792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.13.4083
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