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Promoter-proximal polyadenylation sites reduce transcription activity
Gene expression relies on the functional communication between mRNA processing and transcription. We previously described the negative impact of a point-mutated splice donor (SD) site on transcription. Here we demonstrate that this mutation activates an upstream cryptic polyadenylation (CpA) site, w...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3465738/ https://ncbi.nlm.nih.gov/pubmed/23028143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.189126.112 |
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