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Promoter proximal splice sites enhance transcription

Reconstruction of a gene with its introns removed results in reduced levels of cytoplasmic mRNA. This is partly explained by introns promoting the export of mRNA through coupling splicing to nuclear export processes. However, we show here that splicing signals can have a direct role in enhancing gen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Furger, Andre, Binnie, Justin M. O‘Sullivan, Alexandra, Lee, Barbara A., Proudfoot, Nick J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC187476/
https://ncbi.nlm.nih.gov/pubmed/12414732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.983602
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