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Diastereoselectivity in Lewis-Acid Catalyzed Mukaiyama Aldol Reactions: A DFT Study

The basis for diastereoselectivity in Lewis acid-catalyzed Mukaiyama aldol reactions was studied using density functional theory. By exploring the conformations of the transition structures for the diastereodifferentiating step of seven different reactions, simple models were generated. The effects...

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Bibliografische gegevens
Hoofdauteurs: Lee, Joshua M., Helquist, Paul, Wiest, Olaf
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465709/
https://ncbi.nlm.nih.gov/pubmed/22891640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3052975
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