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Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients

JAGGED1 mutations cause Alagille syndrome, comprising a constellation of clinical findings, including biliary, cardiac and craniofacial anomalies. Jagged1, a ligand in the Notch signaling pathway, has been extensively studied during biliary and cardiac development. However, the role of JAGGED1 durin...

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Main Authors: Humphreys, Ryan, Zheng, Wei, Prince, Lawrence S, Qu, Xianghu, Brown, Christopher, Loomes, Kathleen, Huppert, Stacey S., Baldwin, Scott, Goudy, Steven
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465692/
https://ncbi.nlm.nih.gov/pubmed/22156581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr575
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