Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1 (DNMT1)

To examine the roles of epigenetic modulation on hair follicle regeneration, we generated mice with a K14Cre-mediated loss of DNA methyltransferase (DNMT) 1. The mutant shows an uneven epidermal thickness and alterations in hair follicle size. When formed, hair follicle architecture and differentiat...

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Detalhes bibliográficos
Main Authors: Li, Ji, Jiang, Ting-Xin, Hughes, Michael W., Wu, Ping, Widelitz, Randall B, Fan, Guoping, Chuong, Cheng-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465630/
https://ncbi.nlm.nih.gov/pubmed/22763785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.206
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