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Mechanism for Hypocretin-mediated sleep-to-wake transitions

Current models of sleep/wake regulation posit that Hypocretin (Hcrt)-expressing neurons in the lateral hypothalamus promote and stabilize wakefulness by projecting to subcortical arousal centers. However, the critical downstream effectors of Hcrt neurons are unknown. Here we use optogenetic, pharmac...

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Main Authors: Carter, Matthew E., Brill, Julia, Bonnavion, Patricia, Huguenard, John R., Huerta, Ramon, de Lecea, Luis
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465396/
https://ncbi.nlm.nih.gov/pubmed/22955882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202526109
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