Plasma Uric Acid Levels Correlate with Inflammation and Disease Severity in Malian Children with Plasmodium falciparum Malaria

BACKGROUND: Plasmodium falciparum elicits host inflammatory responses that cause the symptoms and severe manifestations of malaria. One proposed mechanism involves formation of immunostimulatory uric acid (UA) precipitates, which are released from sequestered schizonts into microvessels. Another inv...

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Hauptverfasser: Lopera-Mesa, Tatiana M., Mita-Mendoza, Neida K., van de Hoef, Diana L., Doumbia, Saibou, Konaté, Drissa, Doumbouya, Mory, Gu, Wenjuan, Traoré, Karim, Diakité, Seidina A. S., Remaley, Alan T., Anderson, Jennifer M., Rodriguez, Ana, Fay, Michael P., Long, Carole A., Diakité, Mahamadou, Fairhurst, Rick M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465329/
https://ncbi.nlm.nih.gov/pubmed/23071567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046424
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