Plasma Uric Acid Levels Correlate with Inflammation and Disease Severity in Malian Children with Plasmodium falciparum Malaria

BACKGROUND: Plasmodium falciparum elicits host inflammatory responses that cause the symptoms and severe manifestations of malaria. One proposed mechanism involves formation of immunostimulatory uric acid (UA) precipitates, which are released from sequestered schizonts into microvessels. Another inv...

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Auteurs principaux: Lopera-Mesa, Tatiana M., Mita-Mendoza, Neida K., van de Hoef, Diana L., Doumbia, Saibou, Konaté, Drissa, Doumbouya, Mory, Gu, Wenjuan, Traoré, Karim, Diakité, Seidina A. S., Remaley, Alan T., Anderson, Jennifer M., Rodriguez, Ana, Fay, Michael P., Long, Carole A., Diakité, Mahamadou, Fairhurst, Rick M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465329/
https://ncbi.nlm.nih.gov/pubmed/23071567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046424
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