Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases

Alterations in muscle play an important role in common diseases and conditions. Reactive oxygen species (ROS) are generated during hindlimb unloading due, at least in part, to the activation of xanthine oxidase (XO). The major aim of this study was to determine the mechanism by which XO activation c...

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Detalhes bibliográficos
Main Authors: Derbre, Frederic, Ferrando, Beatriz, Gomez-Cabrera, Mari Carmen, Sanchis-Gomar, Fabian, Martinez-Bello, Vladimir E., Olaso-Gonzalez, Gloria, Diaz, Ana, Gratas-Delamarche, Arlette, Cerda, Miguel, Viña, Jose
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465256/
https://ncbi.nlm.nih.gov/pubmed/23071610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046668
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