Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy

In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol (ALP), on cardiac dysfunction, oxidative‐nitrosative stress, apoptosis, poly(ADP‐ribose) polymerase (PARP) activity and fibrosis associated with diabetic cardiomyopathy in mice. Diabetes was induced in C57/...

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Autors principals: Rajesh, Mohanraj, Mukhopadhyay, Partha, Bátkai, Sándor, Mukhopadhyay, Bani, Patel, Vivek, Haskó, György, Szabó, Csaba, Mabley, Jon G., Liaudet, Lucas, Pacher, Pál
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2008
Matèries:
Small Molecules: Molecular Bullets
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819653/
https://ncbi.nlm.nih.gov/pubmed/19175688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00564.x
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