Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy

In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol (ALP), on cardiac dysfunction, oxidative‐nitrosative stress, apoptosis, poly(ADP‐ribose) polymerase (PARP) activity and fibrosis associated with diabetic cardiomyopathy in mice. Diabetes was induced in C57/...

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Detalhes bibliográficos
Main Authors: Rajesh, Mohanraj, Mukhopadhyay, Partha, Bátkai, Sándor, Mukhopadhyay, Bani, Patel, Vivek, Haskó, György, Szabó, Csaba, Mabley, Jon G., Liaudet, Lucas, Pacher, Pál
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2008
Assuntos:
Small Molecules: Molecular Bullets
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819653/
https://ncbi.nlm.nih.gov/pubmed/19175688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00564.x
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