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Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study

BACKGROUND: Arsenic Trioxide (ATO) is effective in about 20% of patients with myelodysplasia (MDS); its mechanisms of action have already been evaluated in vitro, but the in vivo activity is still not fully understood. Since ATO induces apoptosis in in vitro models, we compared the expression of 93...

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Detalhes bibliográficos
Main Authors: Galimberti, Sara, Guerrini, Francesca, Salvi, Flavia, Petrini, Iacopo, Gioia, Daniela, Messa, Emanuela, Palumbo, Giuseppe A, Cilloni, Daniela, Petrini, Mario, Levis, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465246/
https://ncbi.nlm.nih.gov/pubmed/22964015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-5-53
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