Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

BACKGROUND: HIV-1 Nef is a multifunctional protein required for full pathogenicity of the virus. As Nef has no known enzymatic activity, it necessarily functions through protein-protein interaction interfaces. A critical Nef protein interaction interface is centered on its polyproline segment (P(69)...

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Autori principali: Kuo, Lillian S, Baugh, Laura L, Denial, Sarah J, Watkins, Richard L, Liu, Mingjie, Garcia, J Victor, Foster, John L
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464899/
https://ncbi.nlm.nih.gov/pubmed/22651890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-47
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